BY DR. SCOTT NOORDA
Do you know what supplements your doctor is taking?
My patients ask me this all the time. And to be honest, I haven’t always been the most consistent with supplements. I’ve mostly used them when I’m fighting off an illness or recovering from something. But for 2025, I’ve made a commitment to daily, strategic supplementation—not just to maintain my health but to optimize longevity and cellular function.
There’s no shortage of supplements on the market, and it’s easy to feel overwhelmed. Not everything is necessary, and not every supplement will work the same for everyone. Your supplement stack should be based on your individual health status, lab results, lifestyle, and genetics.
For me, I’ve already put in the work to optimize my diet, exercise, sleep, and stress management, so my focus now is on cellular health, mitochondrial function, and long-term brain optimization. After diving deep into the latest longevity research, I’ve chosen these five science-backed supplements to take daily in 2025.
Here’s why they made the cut and how they work.
Aging is, at its core, a decline in cellular energy production—and that’s largely because of mitochondrial dysfunction. Mitochondria are the powerhouses of your cells, responsible for converting food into energy (ATP). But as we age, they become less efficient, accumulate damage, and struggle to keep up with the body’s demands.
This is where Urolithin A comes in. It supports longevity by:
Where It Comes From & Why I Supplement
Urolithin A is produced in the gut when certain polyphenols from foods like pomegranates, walnuts, and raspberries are broken down. But, not everyone’s gut microbiome is capable of producing enough of it—which is why supplementation is so beneficial.
The research on Urolithin A is strong, showing improved muscle endurance, better mitochondrial function, and increased longevity in animal models. It’s one of the most promising mitochondrial-targeted supplements for aging, and that’s why it’s in my stack.
Where To Get It
Timeline Nutrition has a great Urolithin A supplement called Mitopure and it’s one of the most researched and bioavailable forms of Urolithin A.
As always, supplements should be personalized to your health needs. Be sure to consult with your healthcare provider before adding any new supplements to your routine.
While Urolithin A helps clear out and replace damaged mitochondria, NMN helps fuel them.
NMN is a precursor to NAD+, one of the most critical molecules in the body for:
The issue? NAD+ levels decline significantly as we age—some estimates suggest by as much as 50% by middle age. Lower NAD+ levels are associated with fatigue, slower metabolism, cognitive decline, and increased disease risk.
Why I Supplement with NMN
Direct supplementation with NAD+ is generally considered ineffective due to its instability and poor bioavailability when taken orally. This means that NAD+ doesn’t absorb well into the bloodstream when ingested. Instead, the body relies on precursors like NMN (nicotinamide mononucleotide) to boost NAD+ levels.
NMN is an orally bioavailable precursor to NAD+. Once ingested, NMN is efficiently converted into NAD+ within the body, supporting various cellular functions, including energy metabolism and DNA repair.
NMN is naturally present in certain foods, but in relatively small amounts. For example:
Given these concentrations, achieving therapeutic NMN levels through diet alone would require consuming impractically large quantities of these foods. Therefore, NMN supplementation is considered a more effective strategy to support cellular NAD+ levels and promote longevity.
Where To Get It
I’m trying out the NMN Lipo Capsules from Genevity Plus right now. I also have a couple of options (capsule or pump) in my Longevity Stack on Fullscript.
As always, supplements should be personalized to your health needs. Be sure to consult with your healthcare provider before adding any new supplements to your routine.
This one’s fascinating. Methylene blue has been used in medicine for over a century, originally as an antimicrobial agent and later for conditions like malaria, urinary tract infections, and even cyanide poisoning. But what’s caught my attention is its powerful effects on mitochondrial function and brain health.
Here’s what it does:
How I Take It
You can take methylene blue in capsule form from a compounded pharmacy (which is great because it doesn’t stain your mouth blue), or as a liquid solution, which you mix into water. If you go the liquid route, your mouth will turn blue, so be prepared for that!
Methylene blue is being studied for its potential role in preventing neurodegenerative diseases like Alzheimer’s and Parkinson’s, and given my passion for brain health, it’s a no-brainer for me to include it in my daily routine.
Where To Get It
I rarely recommend supplements from Amazon, but methylene blue is harder to find and isn’t available on Fullscript yet. Right now, my best options are this highly-rated one from Amazon or getting it from a compounding pharmacy.
My colleagues at Fusion Pharmacy are compounding it into capsules, which means you can skip the notorious blue tongue look! It is more expensive this way, but for some, the convenience might be worth it. They ship all across the U.S.
As always, check with your healthcare provider before adding new supplements to your routine to ensure they’re right for you.
I’ve never been a fan of generic multivitamins. They tend to contain poorly absorbed forms of nutrients and are often missing key cofactors that the body needs. Instead, I take a high-quality, broad-spectrum multivitamin that is tailored to my genetics—especially my methylation pathways.
For example, many people (myself included) have variations in the MTHFR gene, which affects how the body metabolizes folate. This means I need the activated form, methylfolate, instead of folic acid. The same goes for B12—I take methylcobalamin instead of cyanocobalamin.
This kind of personalized approach ensures that I’m getting the exact nutrients my body needs for:
Where To Get It
You can find my preferred multivitamin, O.N.E. by Pure Encapsulations, in my Longevity Stack on Fullscript.
As always, supplements should be personalized to your health needs. Be sure to consult with your healthcare provider before adding any new supplements to your routine.
Omega-3 fatty acids are crucial for brain health, heart health, and reducing inflammation. But here’s the problem—most people (including me) don’t get enough from diet alone.
Since I live in landlocked Utah, I don’t have easy access to high-quality, wild-caught fish. And while I do eat sources of Omega-3s like walnuts, flaxseeds, and chia seeds, the EPA and DHA found in fish oil are more bioavailable and beneficial for the brain.
Omega-3s support:
A high-dose, high-quality Omega-3 supplement ensures that I’m consistently getting the right balance of EPA and DHA to support longevity and overall health.
Where To Get It
I’m a big fan of Nordic Naturals ProOmega 2000-D because it combines Omega-3s with Vitamin D, making it a highly effective option. Nearly everyone I test is low in Vitamin D, so having it included in a high-quality Omega-3 supplement is a great way to ensure adequate intake. You can find it in my Longevity Stack on Fullscript.
As always, supplements should be personalized to your health needs. Be sure to consult with your healthcare provider before adding any new supplements to your routine.
Longevity isn’t just about adding years to your life—it’s about maintaining quality of life as you age. These supplements are not replacements for a healthy lifestyle, but they provide targeted cellular support that can enhance energy, brain function, and resilience against aging.
RESEARCH + RESOURCES
The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial The use of a systems approach to increase NAD+ in human participants
NMN (Nicotinamide Mononucleotide): Benefits, Side Effects, and Dosage
Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy
Urolithin A as a Potential Agent for Prevention of Age-Related Disease: A Scoping Review.
Targeting aging with urolithin A in humans: A systematic review.
Anti-Aging Potentials of Methylene Blue for Human Skin Longevity.
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